A quinoline alkaloid rich floral extract enhances the bioactivity.

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ID: 1428
2019
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Abstract
A volatile alkaloid quinoline-4-carbonitrile (QCN) was isolated from the floral extract of . Major compounds were -linalool oxide (1.0, 4.5%), methyl benzoate (1.0, 4.0%), 2,2,6-trimethyl-6-vinyl-tetrahydropyran-3-one (7.4, 17.8%), 2,2,6-trimethyl-6-vinyl-tetrahydropyran-3-ol (1.0, 1.2%), ()-α-farnesene (29.1, 16.1%), QCN (5.7, 1.3%) in live and picked flowers, respectively. Flower compositions were altered due to change in enzymatic reaction at the time of picking. Some rearrangements of oxygenated terpenoids occurred in the process of hydrodistillation to obtain essential oil. Chemical synthesis of QCN and its selectively reduced products derived from QCN were prepared through green reaction process. The catalytic modification of QCN has produced quinoline-4-methylamine; the later compound has shown enhanced bio-activities. QCN and floral extract (absolute) have shown potential anti-inflammatory and antioxidant activities. Besides, floral absolute has shown significant anti-inflammatory and antioxidant activities due to improved QCN (19.7%) content to synergize amongst terpenoids and benzenoids as compared to the essential oil with 1.1% of QCN.
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rout2019a Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rout, Prasant Kumar;Kumar, Prashant;Rao, Y Ramachandra;Kumar, Anant;Bawankule, Dnyaneshwar U;Singh, Ruchi;Singh, Kijay Bahadur;Chanotiya, Chandan Singh;Naik, S N;
Journal Natural product research
Year 2019
DOI
10.1080/14786419.2019.1634709
URL
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