the relationship between vegfa and tgfb1 polymorphisms and target lesion revascularization after elective percutaneous coronary intervention

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ID: 141572
2017
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Abstract
Background and Aim. The specific association between genetic variation and in-stent restenosis is still only partly understood. The aim of this study is to analyze the relationship between functional polymorphisms in the genes encoding vascular endothelial growth factor A (VEGF-A; rs699947) and transforming growth factor beta 1 (TGF-β1; rs1800470) and target lesion revascularization (TLR) risk. Methods. A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation were included. The primary study endpoint was TLR at a 4-year follow-up. Results. The TLR rate was higher in patients with the VEGFA A/A genotype (15.4%) than in patients with the VEGFA A/C (7.9%) and C/C (8.9%) genotypes (p=0.009). The VEGFA A/A genotype, after adjustment for clinical and procedural covariates, remained significantly and independently associated with the TLR (hazard ratio—2.09 [95% confidence interval 1.32–3.33, p=0.0017]). However, we found no association between TLR and the TGFB1 genotype. Conclusion. The VEGFA A/A genotype is significantly and independently associated with TLR risk in Polish SCAD patients who received elective PCI with bare-metal stent implantation.
Reference Key
osadnik2017diseasethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tadeusz Osadnik;Andrzej Lekston;Kamil Bujak;Joanna Katarzyna Strzelczyk;Lech Poloński;Mariusz Gąsior
Journal international journal of psychology : journal international de psychologie
Year 2017
DOI
10.1155/2017/8165219
URL
http://dx.doi.org/10.1155/2017/8165219
Keywords
Medicine (General)

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