glucose-regulated protein 78 induced bone marrow–derived dcs maintained tolerogenic signature upon lps stimulation
Clicks: 330
ID: 141563
2016
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Steady Performance
30.0
/100
330 views
72 readers
AI Quality Assessment
Not analyzed
Readership in this journal
SteadyRanked #97 of 644 articles by views in sudebno-meditsinskaia ekspertiza
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 644 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The 78 kDa glucose-regulated protein (Grp78) is stress-inducible chaperone that mostly reside in the endoplasmic reticulum. Grp78 has been described to be released at times of cellular stress and as having extracellular properties that are anti-inflammatoryor favor the resolution of inflammation. As dendritic cells play a critical rolein both the priming of adaptive immune responses and the induction of self-tolerance, herein, we investigated the effect of Grp78 on the maturation of murine bone marrow derived dendritic cells (BMDCs). Results showed that BMDCs could be bound by AF488 labeled Grp78 and that Grp78 treatment induced a tolerogenic DC phenotype comparable to immature DCs. Furthermore, when exposed to LPS, Grp78 treated DC (DCGrp78) did not adopt a mature DC phenotype. DCGrp78-primed T cells exhibited reduced proliferation along with a concomitant expansion of CD4+CD25+FoxP3+ cells in PLNs and induction of T cell apoptosis in vitro and ex vivo. The above work suggests that Grp78 is an immunomodulatory molecule that could aid resolution of inflammation. It may thus contribute to induce durable tolerance to be of potential therapeutic benefit in transplanted allogeneic grafts and autoimmune diseases such as typeⅠdiabetes.
| Reference Key |
yang2016frontiersglucose-regulated
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Muyang Yang;Muyang Yang;Fan Zhang;Kai Qin;Min Wu;Heli Li;Huifen Zhu;Qin Ning;Ping Lei;Guanxin Shen |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2016 |
| DOI |
10.3389/fimmu.2016.00552
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.