architecture and expression of the nfatc1 gene in lymphocytes

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ID: 140634
2014
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Abstract
In lymphocytes, the three NFAT factors NFATc1 (also designated as NFAT2), NFATc2 (NFAT1) and NFATc3 (NFAT4 or NFATx) are expressed and are targets of immune receptor signals which lead to a rapid rise of intracellular Ca++, the activation of phosphatase calcineurin and to activation of cytosolic NFATc proteins. In addition to rapid activation of NFAT factors, immune receptor signals lead to accumulation of the short NFATc1/aA isoform in lymphocytes which controls their proliferation and survival. In this mini-review we summarize our current knowledge on the structure and transcription of the Nfatc1 gene in lymphocytes which is controlled by two promoters, two poly A addition sites and a remote downstream enhancer. The Nfatc1 gene resembles numerous primary response genes (PRGs) induced by LPS in macrophages. Similar to the PRG promoters, the Nfatc1 promoter region is organized in CpG islands, forms DNase I hypersensitive sites and is marked by histone tail modifications before induction. By studying gene induction in lymphocytes in detail it will be important to elucidate whether the properties of the Nfatc1 induction are not only typical for the Nfatc1 gene but also for other transcription factor genes expressed in lymphocytes.
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erudolf2014frontiersarchitecture Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Ronald eRudolf;Rhoda eBusch;Amiya Kumar Patra;Khalid eMuhammad;Andris eAvots;Jean-Christophe eAndrau;Stefan eKlein-Hessling;Edgar eSerfling
Journal sudebno-meditsinskaia ekspertiza
Year 2014
DOI
10.3389/fimmu.2014.00021
URL
http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00021/full
Keywords
epigenetics chromatin lymphocytes gene allergy histone modificationsimmunologic diseases

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