long noncoding rna-mediated activation of androgen receptor in prostate cancer
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ID: 140411
2014
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Abstract
Remarkable progress has been made in molecular characterization of prostate cancer (PCa) with continued innovations in high throughput technologies evaluating human cancer. [1],[2],[3] Since the completion of the Human Genome Project it has been estimated that only about 1.5%-2% of our genome codes for proteins. Various genome-wide approaches, e.g. the ENCODE project, revealed that a much larger percent of the genome is transcribed as non-protein coding (nc) RNA, including long noncoding (lnc) RNA (over 200 bps long). Although the biological roles of lncRNA (the 'dark matter of the genome') are not nearly as well-understood as the protein coding mRNAs, it is increasingly clear that they play important roles in almost every aspects of biology, including cancer biology. [4],[5] This is exemplified by recent genome-wide association studies revealing that over 80% of cancer-associated single nucleotide polymorphisms (SNPs) are in noncoding regions of the genome.
| Reference Key |
petrovics2014asianlong
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|---|---|
| Authors | ;Gyorgy Petrovics;Shiv Srivastava |
| Journal | softwarex |
| Year | 2014 |
| DOI |
10.4103/1008-682X.126398
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| URL | |
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