bombesin-like receptor 3 (brs3) expression in glutamatergic, but not gabaergic, neurons is required for regulation of energy metabolism

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2017
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Abstract
Objective: Bombesin-like receptor 3 (BRS-3) is an orphan G protein-coupled receptor. Brs3 null mice have reduced resting metabolic rate and body temperature, increased food intake, and obesity. Here we study the role of Brs3 in different neuron types. Methods: Mice able to undergo Cre recombinase-dependent inactivation or re-expression of Brs3 were generated, respectively Brs3fl/y and Brs3loxTB/y. We then studied four groups of mice with Brs3 selectively inactivated or re-expressed in cells expressing Vglut2-Cre or Vgat-Cre. Results: Deletion of Brs3 in glutamatergic neurons expressing Vglut2 reproduced the global null phenotype for regulation of food intake, metabolic rate, body temperature, adiposity, and insulin resistance. These mice also no longer responded to a BRS-3 agonist, MK-5046. In contrast, deletion of Brs3 in GABAergic neurons produced no detectable phenotype. Conversely, the wild type phenotype was restored by selective re-expression of Brs3 in glutamatergic neurons, with no normalization achieved by re-expressing Brs3 in GABAergic neurons. Conclusions: Brs3 expression in glutamatergic neurons is both necessary and sufficient for full Brs3 function in energy metabolism. In these experiments, no function was identified for Brs3 in GABAergic neurons. The data suggest that the anti-obesity pharmacologic actions of BRS-3 agonists occur via agonism of receptors on glutamatergic neurons.
Reference Key
xiao2017molecularbombesin-like Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Cuiying Xiao;Ramón A. Piñol;Jesse Lea Carlin;Cuiling Li;Chuxia Deng;Oksana Gavrilova;Marc L. Reitman
Journal Small (Weinheim an der Bergstrasse, Germany)
Year 2017
DOI
10.1016/j.molmet.2017.08.013
URL
http://www.sciencedirect.com/science/article/pii/S2212877817305719
Keywords
obesity energy expenditure food intake body temperatureinternal medicine

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