potential mechanisms underlying the protective effect of pregnancy against breast cancer: a focus on the igf pathway

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ID: 139949
2016
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Abstract
A first full term birth at an early age protects women against breast cancer by reducing lifetime risk by up to 50%. The underlying mechanism resulting in this protective effect remains unclear, but many avenues have been investigated, including lobular differentiation, cell fate, and stromal composition. A single pregnancy at an early age protects women for 30-40 years and this long-term protection is likely regulated by a relatively stable yet still modifiable method, such as epigenetic reprogramming. Long lasting epigenetic modifications have been shown to be induced by pregnancy and to target the IGF pathway. Understanding how an early first full term pregnancy protects against breast cancer and the role of epigenetic reprogramming of the IGF system may aid in developing new preventative strategies for young healthy women in the future.
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katz2016frontierspotential Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tiffany A Katz
Journal international journal of heat and technology
Year 2016
DOI
10.3389/fonc.2016.00228
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2016.00228/full
Keywords
pregnancy insulin-like growth factor i Oncology including cancer and carcinogens tumors breast cancer riskneoplasms

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