breaking immunological tolerance in systemic lupus erythematosus
Clicks: 303
ID: 138915
2014
Article Quality & Performance Metrics
Overall Quality
Improving Quality
0.0
/100
Combines engagement data with AI-assessed academic quality
Reader Engagement
Popular Article
78.6
/100
302 views
242 readers
Trending
AI Quality Assessment
Not analyzed
Abstract
Systemic Lupus Erythematosus (SLE) is a fairly heterogeneous autoimmune disease with a highly complex and not completely known etiology that mainly affects women in the childbearing age. SLE is a prototype type III hypersensitivity reaction in which immune complex depositions cause inflammation and tissue damage in multiple organs. Two distinct cell death pathways, apoptosis and NETosis, are central and crucial processes in the pathogenesis of SLE. There is growing evidence that histone modifications induced by these cell death pathways exert a key role in the induction of autoimmunity. In the current review, we discuss how abnormalities in apoptosis, NETosis and histone modifications may lead to a break of immunological tolerance in SLE.
Abstract Quality Issue:
This abstract appears to be incomplete or contains metadata (112 words).
Try re-searching for a better abstract.
| Reference Key |
epieterse2014frontiersbreaking
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Elmar ePieterse;Johan eVan Der Vlag |
| Journal | sudebno-meditsinskaia ekspertiza |
| Year | 2014 |
| DOI |
10.3389/fimmu.2014.00164
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.