hla-matched living-related conjunctival limbal allograft for bilateral ocular surface disorders: long-term results transplante alogênico inter vivo de limbo conjuntival com pareamento hla em doenças bilaterais da superfície ocular: resultados em longo prazo

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ID: 138520
2008
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Abstract
PURPOSE: To evaluate the long-term outcome of HLA-matched lr-CLAL for bilateral ocular surface disorders. METHODS: A retrospective, non-comparative interventional case series study of 39 eyes of 32 patients with bilateral surface disorders and clinical diagnosis of limbal stem cell deficiency who underwent HLA-matched lr-CLAL. Visual acuity (VA), ambulatory vision (> 20/200) and ocular surface stability were evaluated as main outcomes. Donor limbus was obtained from a sibling or a parent of the patient, after an appropriate Class I and II HLA match. RESULTS: One year after surgery, VA improved in 46.2%, ambulatory vision was achieved in 48.7% and a stable corneal surface was achieved in 84.6% of the eyes. At the final follow-up (mean, 48.7 ± 30.6 months), 66.6% of the eyes that had gained VA one year after surgery maintained an improved VA (p=0.28), 94.7% of eyes that had achieved ambulatory vision one year after surgery maintained 20/200 or better (p<0.001) and 93.9% still had a stable corneal surface (p=0.043) at the final follow-up. CONCLUSIONS: HLA-matched lr-CLAL can be an adequate method of treatment for bilateral ocular surface disorders, with a reasonable percentage of success of long-term results.
OBJETIVO: Avaliar os resultados em longo prazo do transplante alogênico inter vivo de limbo conjuntival para doenças bilaterais da superfície ocular com compatibilidade HLA doador-receptor. MÉTODOS: Estudo retrospectivo, não comparativo e intervencionista de 39 olhos de 32 pacientes submetidos a transplante alogênico de limbo com compatibilidade HLA e diagnóstico de deficiência límbica. Foram analisados como desfechos principais acuidade visual, visão ambulatorial (> 20/200) e estabilidade da superfície ocular. Limbo doador foi obtido de parentes do paciente após estudo de compatibilidade HLA classe I e II. RESULTADOS: Com um ano de pós-operatório, a acuidade visual melhorou em 46,2%, visão ambulatorial foi atingida em 48,7% e estabilidade da superfície corneana em 84,6% dos pacientes. Ao final do seguimento (média, 48,7 ± 30,6 meses), 66,6% dos olhos que haviam ganho acuidade visual um ano após a cirurgia mantiveram esta melhora (p=0,28), 94,7% dos olhos que haviam alcançado visão ambulatorial um ano após a cirurgia mantiveram visão de 20/200 ou melhor (p<0,001) e 93,9% ainda tinham superfície corneana estável (p=0,043) ao final do seguimento. CONCLUSÕES: O transplante alogênico inter vivo de limbo conjuntival com compatibilidade HLA revelou-se método adequado no tratamento de doenças bilaterais da superfície ocular, com uma porcentagem significativa de sucesso a longo-prazo.
Reference Key
scocco2008arquivoshla-matched Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Caio Scocco;Sérgio Kwitko;Samuel Rymer;Diane Marinho;Francisco Bocaccio;Rodrigo Lindenmeyer
Journal introducing innodb cluster: learning the mysql high availability stack
Year 2008
DOI
10.1590/S0004-27492008000600003
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492008000600003
Keywords
transplantation homologous hla antigensophthalmology

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