promotion of tumor invasion by cooperation of granulocytes and macrophages activated by anti-tumor antibodies

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ID: 138304
1999
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Abstract
We investigated the potential role of anti-tumor antibodies and tumor antigens in the formation of immune complexes which promote matrix degradation and angiogenesis. B-cell deficient or B-cell depleted mice showed a reduction in tumor invasion and metastasis. In vitro invasion assays and in vivo models of metastasis showed that anti-sTn antibodies and sTn tumor antigens form complexes which induce granulocytes and macrophages together to mediate tumor invasion and metastasis by processes including extracellular matrix degradation and angiogenesis. These results suggest the existence of a tumor promoting role of a B-cell immune response induced by shed tumor associated antigens of solid, nonlymphoid tumors.
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Authors ;Emilio Barbera-Guillem;Kenneth F. May, Jr.;Julie K. Nyhus;M. Bud Nelson
Journal ACS chemical neuroscience
Year 1999
DOI
10.1038/sj.neo.7900054
URL
http://www.sciencedirect.com/science/article/pii/S1476558699800177
Keywords
metastasis b cells Oncology granulocytes including cancer and carcinogens tumors macrophagesneoplasms

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