synthesis of oxylipin mimics and their antifungal activity against the citrus postharvest pathogens

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ID: 138282
2016
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Abstract
Nine oxylipin mimics were designed and synthesized starting from d-mannose. Their antifungal activity against three citrus postharvest pathogens was evaluated by spore germination assay. The results indicated that all the compounds significantly inhibited the growth of Penicillium digitatum, Penicillium italicum and Aspergillus niger. The compound (3Z,6Z,8S,9R,10R)-octadeca-3,6-diene-8,9,10-triol (3) exhibited excellent inhibitory effect on both Penicillium digitatum (IC50 = 34 ppm) and Penicillium italicum (IC50 = 94 ppm). Their in vivo antifungal activities against citrus postharvest blue mold were tested with fruit inoculated with the pathogen Penicillium italicum. The compound (3R,4S)-methyl 3,4-dihydroxy-5-octyltetrahydrofuran-2-carboxylate (9) demonstrated significant efficacy by reducing the disease severity to 60%. The antifungal mechanism of these oxylipin mimics was postulated in which both inhibition of pathogenic mycelium and stimuli of the host oxylipin-mediated defense response played important roles.
Reference Key
ma2016moleculessynthesis Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jimei Ma;Yupeng Li;Hangwei Chen;Zhen Zeng;Zi-Long Li;Hong Jiang
Journal Journal of ethnopharmacology
Year 2016
DOI
10.3390/molecules21020254
URL
http://www.mdpi.com/1420-3049/21/2/254
Keywords
synthesis Citrus Antifungal Activity pathogenorganic chemistry

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