crystal structure and absolute configuration of (3s,4as,8as)-n-tert-butyl-2-[(s)-3-(2-chloro-4-nitrobenzamido)-2-hydroxypropyl]decahydroisoquinoline-3-carboxamide and (3s,4as,8as)-n-tert-butyl-2-{(s)-2-[(s)-1-(2-chloro-4-nitrobenzoyl)pyrrolidin-2-yl]-2-hydroxyethyl}decahydroisoquinoline-3-carboxamide

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ID: 138266
2015
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Abstract
The crystal structure and absolute configuration of the two new title nelfinavir analogs, C24H35ClN4O5, (I), and C27H39ClN4O5, (II), have been determined. Each of these molecules exhibits a number of disordered moieties. There are intramolecular N—H...O hydrogen bonds in both (I) and (II). In (I) it involves the two carboxamide groups, while in (II) it involves the N-tert-butyl carboxamide group and the 2-hydroxyl O atom. The intermolecular hydrogen bonding in (I) (O—H...O and N—H...O) leads to two-dimensional sheets that extend parallel to the ac plane. The intermolecular hydrogen bonding in (II) (O—H...O) leads to chains that extend parallel to the a axis.
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maxson2015actacrystal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Tucker Maxson;Jeffery A. Bertke;Danielle L. Gray;Douglas A. Mitchell
Journal Disability and rehabilitation
Year 2015
DOI
10.1107/S2056989015020046
URL
http://scripts.iucr.org/cgi-bin/paper?S2056989015020046
Keywords
crystal structure absolute configuration

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