optimization of cultivation medium for the production of antibacterial agents
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ID: 138154
2013
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Abstract
Optimization of the cultivation medium for production of antibiotic effective
against pathogenic bacteria Staphylococcus aureus using strain of
Streptomyces spp. isolated from the environment represents the aim of this
study. After the biosynthesis, the medium was analyzed by determining
residual sugar and nitrogen, and the antibiotic activity was determined using
diffusion-disc method. Experiments were carried out in accordance with the
Box-Behnken design, with three factors varied on three levels (glucose: 10.0,
30.0 and 50.0 g/L; soybean meal: 5.0, 15.0 and 25.0 g/L; phosphates: 0.5, 1.0
and 1.5 g/L) and for the optimization of selected parameters Response Surface
Methodology was used. The obtained model with the desirability function of
0.985 estimates that the lowest amounts of residual sugar (0.89 g/L) and
nitrogen (0.24 g/L) and the largest possible inhibition zone diameter (21.88
mm) that with its antibiotic activity against S. aureus creates the medium
containing 10.0 g/L glucose, 5.0 g/L soybean meal and 1.04 g/L phosphates.
| Reference Key |
a.2013actaoptimization
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|---|---|
| Authors | ;Grahovac Jovana A.;Bajić Bojana Ž.;Dodić Jelena M.;Rončević Zorana Z.;Jokić Aleksandar I. |
| Journal | chemical papers |
| Year | 2013 |
| DOI |
10.2298/APT1344217G
|
| URL | |
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