genetic modulation of training and transfer in older adults:bdnf val66met polymorphism is associated with wider useful field of view
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ID: 138138
2011
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Abstract
Western society has an increasing proportion of older adults. Increasing age is associated with a general decrease in the control over task-relevant mental processes. In the present study we investigated the possibility that successful transfer of game-based cognitive improvements to untrained tasks in elderly people is modulated by preexisting neuro-developmental factors as genetic variability related to levels of the brain-derived neurotrophic factor (BDNF), an important neuromodulator underlying cognitive processes. We trained participants, genotyped for the BDNF Val66Met polymorphism, on cognitive tasks developed to improve dynamic attention. Pre-training (baseline) and post-training measures of attentional processes (divided and selective attention) were acquired by means of the Useful Field of View (UFOV) task. As expected, Val/Val homozygous individuals showed larger beneficial transfer effects than Met/-carriers. Our findings support the idea that genetic predisposition modulates transfer effects.
| Reference Key |
colzato2011frontiersgenetic
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|---|---|
| Authors | ;Lorenza S Colzato;Jesse evan Muijden;Guido P H Band;Bernhard eHommel |
| Journal | accounts of chemical research |
| Year | 2011 |
| DOI |
10.3389/fpsyg.2011.00199
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| URL | |
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