a novel mechanism for switching a neural system from one state to another

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ID: 137937
2010
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Abstract
An animal’s ability to rapidly adjust to new conditions is essential to its survival. The nervous system, then, must be built with the flexibility to adjust, or shift, its processing capabilities on the fly. To understand how this flexibility comes about, we tracked a well-known behavioral shift, a visual integration shift, down to its underlying circuitry, and found that it is produced by a novel mechanism – a change in gap junction coupling that can turn a cell class on and off. The results showed that the turning on and off of a cell class shifted the circuit’s behavior from one state to another, and, likewise, the animal’s behavior. The widespread presence of similar gap junction-coupled networks in the brain suggests that this mechanism may underlie other behavioral shifts as well.
Reference Key
pandarinath2010frontiersa Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Chethan Pandarinath;Illya Bomash;Jonathan D Victor;Glen T Prusky;Wayne Tschetter;Sheila Nirenberg
Journal population health management
Year 2010
DOI
10.3389/fncom.2010.00002
URL
http://journal.frontiersin.org/Journal/10.3389/fncom.2010.00002/full
Keywords
horizontal cell adaptation attention gap junction cable theory neuropsychiatry biological psychiatry network shiftneurosciences

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