dynamic changes in plasma cd62p and their significance among patients with obstructive jaundice and cholecystolithiasis
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2014
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Abstract
ObjectiveTo analyze and study the implication of dynamic changes in plasma CD62P among patients with obstructive jaundice and cholecystolithiasis. MethodsA total of 58 patients diagnosed with choledocholithiasis and jaundice were included in the obstructive jaundice group, and 50 patients were in the cholecystolithiasis group. Peripheral venous blood was collected on preoperative day 3, on operative day, and on postoperative days 3, 6, 9, 12, 15, 18, and 21 in two groups, and the concentrations of plasma CD62P were measured by ELISA. Comparison of continuous data between the two groups was made by t test. ResultsThe concentrations of plasma CD62P from preoperative day 3 to postoperative day 18 were significantly higher in the obstructive jaundice group than in the cholecystolithiasis group (P＜001 across all time points). In the cholecystolithiasis group, the concentrations of plasma CD62P significantly increased on operative day, and the increase continued and reached the peak on postoperative day 3, then followed by a decrease down to the preoperative level on postoperative day 9. In the obstructive jaundice group, the concentrations of plasma CD62P reached the peak on postoperative day 9, followed by a gradual decrease down to the preoperative level on postoperative day 18 and to an even lower level (preoperative level of patients with cholecystolithiasis) on postoperative day 21. ConclusionExtrahepatic biliary obstruction may lead to endothelial cell injury and platelet activation, the condition of which is improved with the relief of obstruction. The surgery for obstructive jaundice may lead to much more endothelial cell injury and higher platelet activation than that for cholecystolithiasis.
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yuhuai2014linchuangdynamic
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| Authors | ;ZHANG Yuhuai |
| Journal | lontar komputer |
| Year | 2014 |
| DOI |
10.3969/j.issn.1001-5256.2014.11.016
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