stability of epidoxorubicin hydrochloride in aqueous solutions: experimental and theoretical studies
Clicks: 99
ID: 136793
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This
article has not been analysed, so there is no overall score —
reader engagement is measured and shown alongside.
Reader Engagement
Emerging Content
29.4
/100
99 views
1 readers
AI Quality Assessment
Not analyzed
Readership in this journal
EmergingRanked #175 of 215 articles by views in british journal of psychology (london, england : 1953)
Most read
Least read
Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 215 in total.
Mint this article as an NFT
Not yet mintedCreate a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.
5
SUSD
one-off · no wallet required
Abstract
The first-order degradation kinetics of epidoxorubicin were investigated as a function of pH, temperature, and buffers concentrations. The degradation was followed by HPLC. Buffer catalysis was observed in acetate and phosphate buffers. The pH-rate profiles were obtained at 333, 343, 353, and 363 K. The pH-rate expression was kpH=k1×aH+×f1+k2×f1+k3×f2+(k4×f2+k5×f3)×aOH-, where k1, k4, and k5 are the second-order rate constants (mol−1 L s−1) for hydrogen ion activity and for hydroxyl ion activity, respectively, and k2 and k3 are the first-order constants (s−1) for spontaneous reaction under the influence of water. Epidoxorubicin demonstrates the greatest stability in the pH range 3–5. The electrostatic molecular potential orbitals HOMO-LUMO were also defined in order to determine the cause of the reactivity of particular epidoxorubicin molecule domains in solutions with various pH values.
| Reference Key |
sobczak2017journalstability
Use this key to autocite in the manuscript while using
SciMatic Manuscript Manager or Thesis Manager
|
|---|---|
| Authors | ;Agnieszka Sobczak;Monika A. Lesniewska-Kowiel;Izabela Muszalska;Artur Firlej;Judyta Cielecka-Piontek;Szymon Tomczak;Bolesław Barszcz;Irena Oszczapowicz;Anna Jelińska |
| Journal | british journal of psychology (london, england : 1953) |
| Year | 2017 |
| DOI |
10.1155/2017/8107140
|
| URL | |
| Keywords |
Citations
No citations found. To add a citation, contact the admin at info@scimatic.org
Comments
No comments yet. Be the first to comment on this article.