amino acid oncometabolism and immunomodulation of the tumor microenvironment in lung cancer

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ID: 136726
2020
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Abstract
The observation that cancer acquires significant changes in its metabolism dates back nearly a century, to Otto Warburg noting that cancer cells preferentially utilize glycolysis even when there are no hypoxic conditions in the growth media. Altered energetics are thus considered a hallmark of cancer. However, it has become clear that altered metabolism is not limited to cellular energetic pathways. Alterations in amino acid synthesis and catabolism, lipid biogenesis, and other pathways such as polyamine processing are commonly seen in cancer. Additionally, alterations in metabolism do not only have profound effects for cancer cells but also affect their surrounding microenvironment. With new cancer therapeutics targeting the immune microenvironment, these effects may have implications on cancer growth and response to therapy. These interactions are profound in lung cancer, further demonstrating the manifold interactions between developing tumors and the inflammatory microenvironment. Here, we discuss how dysregulation of metabolism in cancer alters its microenvironment and how this newfound knowledge can be exploited for anticancer treatment.
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fahrmann2020frontiersamino Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Johannes F. Fahrmann;Jody V. Vykoukal;Edwin J. Ostrin
Journal international journal of heat and technology
Year 2020
DOI
10.3389/fonc.2020.00276
URL
https://www.frontiersin.org/article/10.3389/fonc.2020.00276/full
Keywords
lung cancer glutamate asparagine aspartate tryptophan Oncology including cancer and carcinogens tumors

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