aspectos genéticos da obesidade genetics of obesity

Clicks: 309
ID: 136650
2004
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Abstract
A obesidade definida como a acumulação excessiva de gordura corporal deriva de um desequilíbrio crônico entre a energia ingerida e a energia gasta. Neste desequilíbrio podem estar implicados diversos fatores relacionados com o estilo de vida (dieta e exercício físico), alterações neuro-endócrinas, juntamente com um componente hereditário. O componente genético constitui um fator determinante de algumas doenças congênitas e um elemento de risco para diversas doenças crônicas como diabetes, osteoporose, hipertensão, câncer, obesidade, entre outras. O aumento da prevalência da obesidade em quase todos os países durante os últimos anos, parece indicar que existe uma predisposição ou susceptibilidade genética para a obesidade, sobre a qual atuam os fatores ambientais relacionados com os estilos de vida, em que se incluem principalmente os hábitos alimentares e a atividade física. A utilização de modelos animais de obesidade, a transferência génica e os estudos de associação e ligamento, permitiram a identificação de vários genes implicados na obesidade.
Obesity, defined as an excessive body fat accumulation, is caused by a chronic imbalance between energy intake and energy expenditure. Several factors have been associated with this energy imbalance, such as life style (diet and physical activity), neuroendocrine disorders, together with the genetic background. The genetic background is a major determinant factor of some congenital diseases and a risk factor for some chronic disorders, such as diabetes, osteoporosis, hypertension, cancer, obesity, and others. The increased prevalence of obesity in most countries during the last years, seems to indicate that there is a genetic predisposition or susceptibility to be obese which is increased by environmental and life style factors, mainly by food habits and physical in activity. The use of obesity animal models, genetic transfer and the association and linkage studies leaded to the identification of many genes associated with obesity.
Reference Key
marques-lopes2004revistaaspectos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Iva Marques-Lopes;Amelia Marti;María Jesús Moreno-Aliaga;Alfredo Martínez
Journal statistics
Year 2004
DOI
10.1590/S1415-52732004000300006
URL
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732004000300006
Keywords
obesity polymorphism mutation genes foods and food supply

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