definition of microscopic tumor clearance (r0) in pancreatic cancer resections

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ID: 135740
2010
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Abstract
To date, curative resection is the only chance for cure for patients suffering from pancreatic ductal adenoacarcinoma (PDAC). Despite low reported rates of microscopic tumor infiltration (R1) in most studies, tumor recurrence is a common finding in patients with PDAC and contributes to extremely low long-term survival rates. Lack of international definition of resection margins and of standardized protocols for pathological examination lead to high variation in reported R1 rates. Here we review recent studies supporting the hypothesis that R1 rates are highly underestimated in certain studies and that a microscopic tumor clearance of at least 1 mm is required to confirm radicality and to serve as a reliable prognostic and predictive factor.
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esposito2010cancersdefinition Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Irene Esposito;Anna Melissa Schlitter
Journal The Journal of investigative dermatology
Year 2010
DOI
10.3390/cancers2042001
URL
http://www.mdpi.com/2072-6694/2/4/2001/
Keywords
Pancreatic cancer r1 Oncology including cancer and carcinogens tumors

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