secondary glioblastoma multiforme in a child with disseminated juvenile pilocytic astrocytoma

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ID: 135713
2012
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Abstract
Secondary glioblastoma multiforme (sGBM) can occur after a long latency period following radiation treatment of various diseases including brain tumors, leukemia, and more benign disorders like tinea capitis. Outcomes of radiation-induced sGBM remain poor in both children and adults. We report a case of a 16-year-old girl with a history of disseminated juvenile pilocytic astrocytoma treated with chemotherapy and craniospinal radiation 9 years prior who developed sGBM in the absence of a tumor predisposition syndrome. She presented with a several-week history of headaches and no acute findings on computed tomography compared to baseline neuroimaging 3 months prior. Repeat computed tomography performed just 3 weeks later for worsening headaches revealed a new large posterior fossa tumor where pathology confirmed the diagnosis of sGBM. In spite of maximal surgical resection, reirradiation, and adjuvant chemotherapy, she died 1 year postdiagnosis. Our case highlights the potential late effects of high-dose cranial radiation, how symptomatology may precede neuroimaging findings, and the rapid formation of sGBM that mirrors that of de novo Glioblastoma Multiforme.
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amene2012casesecondary Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;C. S. Amene;L. A. Yeh-Nayre;J. R. Crawford
Journal aaps pharmscitech
Year 2012
DOI
10.1155/2012/290905
URL
http://dx.doi.org/10.1155/2012/290905
Keywords
neoplasms Oncology including cancer and carcinogens tumors

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