in vivo screening antifungal activity of methanolic extract of protoparmeliopsis muralis against aspergillus flavus
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ID: 135076
2017
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Abstract
Background & Objective: Lichens are the result of the symbiosis of fungi and algae or a cyanobacterium. Various biological activities of some lichen and their components such as: antifungal, anti-bacterial, anti-tumor, anti-inflammatory, antiprotozoal substances are known. In the present study, antifungal activity of methanolic extract of Protoparmeliopsis muralis against Aspergillus flavus is investigated on rats.
Materials & Methods: 500 g of Protoparmeliopsis muralis was collected from KaneGonbad mountains in Ilam province, the methanol extract was prepared by soxhle. In order to determine the antifungal activity in in vivo conditions, a wound was created and infected with Aspergillus flavus. Having infected the wound, the researchers divided the rats into 4 subgroups: negative control group, treated with Kotrimoksazol, %5 ointment extract methanolic P. muralis, and with %10 ointment extract methanolic P. muralis. Treatment continued until complete healing of the wound. Finally, the percentage of wound healing was calculated.
Results: The result of the present study demonstrated that methanolic extract of P. muralis decreased the area of wound in the treatment group compared to the control group.
Conclusion: The antifungal and antioxidant activity of the extract of Protoparmeliopsis muralis accelerated the wound healing process.
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| Authors | ;Somaye Rashki;Tahereh Valadbeigi |
| Journal | artificial cells, nanomedicine, and biotechnology |
| Year | 2017 |
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