acute erythroid toxicity in visceral leishmaniasis: a rare complication of antimonial therapy

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ID: 134836
2008
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Abstract
The spectrum of side-effects of sodium stibogluconate is well described, however, little is known regarding the acute erythroid toxicity caused by this drug. We hereby present a case with this unusual complication of antimonial therapy. A 6-year-old male with leishmaniasis was started on parenteral sodium stibogluconate. During the course of treatment, his hemoglobin (Hb) dropped from 7.2 g/dl to 3.5 g/dl. Bone-marrow aspirate showed karyorrhexis in many erythroid precursors with several Leishmania donovanii bodies. Sodium stibogluconate was stopped and amphotericin-B was started. Four days after the cessation of the antimonials, the patient′s Hb improved to 5 gm/dl with a corrected reticulocyte count of 10% indicating bone-marrow erythroid regeneration. The exact mechanism of this acute erythroid toxicity of sodium stibogluconate remains unexplored.
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sunita2008indianacute Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Sharma Sunita;Malhan Priya;Pujani Mukta;Rath B
Journal journal of materials processing technology
Year 2008
DOI
DOI not found
URL
http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2008;volume=51;issue=4;spage=546;epage=547;aulast=Sharma
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