the inhibitory effects of djulis (chenopodium formosanum) and its bioactive compounds on adipogenesis in 3t3-l1 adipocytes

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ID: 134834
2018
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Abstract
The aim of this study was to provide new insights into the role of the ethanolic extracts of Djulis (Chenopodium formosanum, EECF) and its bioactive compounds in preventing adipogenesis in 3T3-L1 adipocytes. The results demonstrated EECF significantly inhibited oil red O-stained material (OROSM), triglyceride levels and glycerol-3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes. The expression of the critical molecules involved in lipid synthesis such as PPARγ, C/EBPα and SREBP-1c was attenuated in EECF-treated cells. According to HPLC-DAD and HPLC-MS/MS analysis, rutin, kaempferol, betanin and another nine compounds were present in EECF. The suppression of lipid accumulation by rutin, kaempferol and betanin occurred by decreasing the gene expression of PPARγ, C/EBPα and SREBP-1c. Taken together, these findings suggest the presence of bioactive compounds in EECF may partly account for the anti-adipogenesis of EECF and EECF is therefore a potentially lipid lowering functional food.
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chyau2018moleculesthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Charng-Cherng Chyau;Chin-Chen Chu;Shih-Ying Chen;Pin-Der Duh
Journal Journal of ethnopharmacology
Year 2018
DOI
10.3390/molecules23071780
URL
http://www.mdpi.com/1420-3049/23/7/1780
Keywords
Rutin kaempferol adipogenesis lipid accumulation djulis (chenopodium formosanum)

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