pathophysiology of cd4+ t-cell depletion in hiv-1 and hiv-2 infections

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ID: 134393
2017
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Abstract
The hall mark of human immunodeficiency virus (HIV) infection is a gradual loss of CD4+ T-cells and imbalance in CD4+ T-cell homeostasis, with progressive impairment of immunity that leads ultimately to death. HIV infection in humans is caused by two related yet distinct viruses: HIV-1 and HIV-2. HIV-2 is typically less virulent than HIV-1 and permits the host to mount a more effective and sustained T-cell immunity. Although both infections manifest the same clinical spectrum, the much lower rate of CD4+ T-cell decline and slower progression of disease in HIV-2 infected individuals have grabbed the attention of several researchers. Here, we review the most recent findings on the differential rate of decline of CD4+ T-cell in HIV-1 and HIV-2 infections and provide plausible reasons for the observed differences between the two groups.
Reference Key
vijayan2017frontierspathophysiology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;K. K. Vidya Vijayan;Krithika Priyadarshini Karthigeyan;Srikanth P. Tripathi;Luke Elizabeth Hanna
Journal sudebno-meditsinskaia ekspertiza
Year 2017
DOI
10.3389/fimmu.2017.00580
URL
http://journal.frontiersin.org/article/10.3389/fimmu.2017.00580/full
Keywords
hiv-1 pyroptosis immune activation allergy

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