b cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland

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ID: 134114
2017
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Abstract
AIM: To detect the expression of B cell receptor signaling pathway (BCRSP) in lacrimal gland benign lymphoepithelial lesions (LGBLEL). METHODS: Gene microarray was used to compare whole-genome expression in lacrimal gland tissues from LGBLEL patients to tissues from orbital cavernous hemangioma (control tissues). Expression of BCRSP was confirmed by polymerase chain reaction (PCR) and immunohistochemistry. RESULTS: The expression of 22 genes of the BCRSP increased significantly in LGBLEL patients. PCR analysis showed that CD22, CR2, and BTK were all highly expressed in LGBLEL tissues. Immunohistochemical analysis showed that CR2 protein was present in LGBLEL, but CD22 and BTK proteins were negative. CR2, CD22, and BTK were not observed in the orbital cavernous hemangiomas with either PCR or immunohistochemistry. CONCLUSION: BCRSP might be involved in the pathogenesis of LGBLEL.
Reference Key
wang2017internationalb Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xiao-Na Wang;Xin Ge;Jing Li;Xiao Liu;Jian-Min Ma
Journal The Classical Review
Year 2017
DOI
10.18240/ijo.2017.05.01
URL
http://www.ijo.cn/en_publish/2017/5/20170501.pdf
Keywords Keywords not found

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