mechanism of c-met in non-small cell lung cancer and its treatment and testing

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ID: 134030
2015
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Abstract
Hepatocyte growth factor/c-MET (HGF/c-MET) signaling pathway can be abnormal activated by many mechanisms such as c-MET mutation, amplification and the overexpression of HGF, and it plays an important role in the development of non-small cell lung cancer (NSCLC), as well as in the tolerance of epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) in NSCLC. Therefore, c-MET is a new molecular target for the therapy of NSCLC since EGFR and ALK. At present, although the c-MET inhibitors have shown a potential prospect in some clinical trials, its assessment of safety and effectiveness in clinical applications, and the choice of testing methods and standards still need a further discussion. In this paper, we summarized the mechanism of c-MET in NSCLC, as well as its treatment prospect and selection of testing methods.
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Authors ;Hongge LIANG;Mengzhao WANG
Journal proceedings of the 10th acm multimedia systems conference, mmsys 2019
Year 2015
DOI
10.3779/j.issn.1009-3419.2015.12.06
URL
http://dx.doi.org/10.3779/j.issn.1009-3419.2015.12.06
Keywords
treatment lung neoplasms Oncology including cancer and carcinogens tumors testingneoplasms

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