the circular rna hsa_circ_0001445 regulates the proliferation and migration of hepatocellular carcinoma and may serve as a diagnostic biomarker
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2018
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Abstract
Circular RNAs (circRNA), a class of noncoding RNAs, have been found to be involved in various diseases. Here, the expression levels of the circRNA hsa_circ_0001445 in 73 pairs of hepatocellular carcinoma (HCC) and adjacent nontumor tissues were investigated by quantitative real-time polymerase chain reaction (qRT-PCR). Our data demonstrate that the hsa_circ_0001445 levels were significantly decreased in HCC tissues (P<0.001) and markedly associated with the number of tumor foci (P=0.014). Furthermore, in vitro approaches showed that overexpression of hsa_circ_0001445 promoted apoptosis and inhibited proliferation, migration, and invasion of HCC-derived cells, suggesting that hsa_circ_0001445 might be involved in the development of HCC. In addition, we found that the plasma hsa_circ_0001445 transcription levels in HCC patients were lower than those in cirrhosis (P<0.001) and hepatitis B (P<0.001) patients as well as in healthy controls (P<0.001). In fact, receiver operating characteristic curve analysis indicated that plasma hsa_circ_0001445 could be a fairly accurate marker to distinguish HCC cases from healthy controls as well as patients with cirrhosis or hepatitis B.
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| Reference Key |
zhang2018diseasethe
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|---|---|
| Authors | ;Xianwei Zhang;Hu Zhou;Wei Jing;Ping Luo;Shili Qiu;Xuefang Liu;Man Zhu;Chunzi Liang;Mingxia Yu;Jiancheng Tu |
| Journal | international journal of psychology : journal international de psychologie |
| Year | 2018 |
| DOI |
10.1155/2018/3073467
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| URL | |
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