fibroblast growth factor 23 and klotho protein in the pathogenesis of secondary hyperparathyroidism
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ID: 133397
2013
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Abstract
One of the main problems in patients with chronic kidney disease (CKD) is a disturbance of calcium-phosphorus metabolism, especially in chronic hemodialysis. Besides classical endocrine axis parathyroid-kidney, in recent years was established the existence of a new endocrine axis the bone-kidney, which gives a better explanation of the calcium and phosphorus metabolism abnormalities, pathophysiology of secondary hyperparathyroidism in CKD. FGF23 is a circulating factor synthesized in osteocytes. It inhibits renal phosphate reabsorption and activity of 1-alphahydroxylase. Anti-aging Klotho protein is a potent co-factor of FGF23. This review presents the mechanisms of the interaction of these elements of the newly discovered axis in normal settings and secondary hyperparathyroidism.
| Reference Key |
ilin2013osteoporozfibroblast
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|---|---|
| Authors | ;A V Ilin;M I Arbuzova |
| Journal | journal of interprofessional care |
| Year | 2013 |
| DOI |
10.14341/osteo2013320-27
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| URL | |
| Keywords | Keywords not found |
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