immunotherapy of invasive fungal infection in hematopoietic stem cell transplant recipients

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ID: 132954
2013
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Resumo
Despite the availability of new antifungal compounds, invasive fungal infection remains a significant cause of morbidity and mortality in children and adults undergoing allogeneic hematopoietic stem cell transplantation (HSCT). Allogeneic HSCT recipients suffer from a long lasting defect of different arms of the immune system, which increases the risk for and deteriorates the prognosis of invasive fungal infections. In turn, advances in understanding these immune deficits have resulted in promising strategies to enhance or restore critical immune functions in allogeneic HSCT recipients. Potential approaches include the administration of granulocytes, since neutropenia is the single most important risk factor for invasive fungal infection, and preliminary clinical results suggest a benefit of adoptively transferred donor-derived antifungal T cells. In vitro data and animal studies demonstrate an antifungal effect of Natural Killer cells, but clinical data are lacking to date. This review summarizes and critically discusses the available data of immunotherapeutic strategies in allogeneic HSCT recipients suffering from invasive fungal infection.
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elehrnbecher2013frontiersimmunotherapy Use esta chave para citacao automatica no manuscrito ao usar SciMatic Gerenciador de Manuscritos ou Gerenciador de Teses
Autores ;Thomas eLehrnbecher;Stanislaw eSchmidt;Lars eTramsen;Thomas eKlingebiel
Periodico international journal of heat and technology
Ano 2013
DOI
10.3389/fonc.2013.00017
URL
http://journal.frontiersin.org/Journal/10.3389/fonc.2013.00017/full
Palavras-chave
immunotherapy natural killer cell t cell allogeneic hematopoietic stem cell transplantation invasive fungal infection Oncology including cancer and carcinogens tumors

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