the use of radioactive marker as a tool to evaluate the drug release in plasma and particle biodistribution of block copolymer nanoparticles
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ID: 132760
2011
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Abstract
Diblock copolymer nanoparticles encapsulating a paclitaxel prodrug, Propac 7, have been used to demonstrate the usefulness of a nonmetabolizable radioactive marker, cholesteryl hexadecyl ether (CHE), to evaluate nanoparticle formulation variables. Since CHE did not exchange out of the nanoparticles, the rate of clearance of the CHE could be used as an indicator of nanoparticle stability in vivo. We simultaneously monitored prodrug circulation and carrier circulation in the plasma and the retention of CHE relative to the retention of prodrug in the plasma was used to distinguish prodrug release from nanoparticle plasma clearance. Nanoparticles labelled with CHE were also used to evaluate accumulation of nanoparticles in the tumour. This marker has provided relevant data which we have applied to optimise our nanoparticle formulations.
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johnstone2011journalthe
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| Authors | ;Sharon Johnstone;Steven Ansell;Sherwin Xie;Lawrence Mayer;Paul Tardi |
| Journal | linux dev center, downloaded from http://www linuxdevcenter com/lpt/a/1636 |
| Year | 2011 |
| DOI |
10.1155/2011/349206
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