effects of alprostadil on respiratory parameters and hemodynamics of newborns with persistent pulmonary hypertension
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2017
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Abstract
Objective: To investigate the effects of alprostadil on respiratory parameters and
hemodynamics of newborns with persistent pulmonary hypertension. Methods: According
to random data table method, 80 newborns of pulmonary hypertension were randomly
divided into the control group (n=40) and observation group (n=40), patients in the control
group were given normal frequency ventilation, on the basis of the treatment of the control
group, the observation group received alprostadil. The changes of respiratory parameters and
hemodynamics were compared between the two groups before and after treatment. Results:
The levels of respiratory parameters (SaO 2 , PaO 2 , PaCO 2 ) and hemodynamics (PA, PVR, SVR)
in the two groups before treatment were not statistically significant. After treatment, The levels
of SaO 2 , PaO 2 in the two groups were significantly higher than those in the same group before
treatment, and the observation group levels were (90.71±8.92)%, (85.27±8.23) mmHg, which
were significantly higher than those in the control group after treatment; The levels of PaCO 2 ,
PA, PVR and SVR in the two groups after treatment were significantly lower than those
in the same group before treatment, and the observation group were (35.22±3.46) mmHg,
(26.95±3.78) mmHg, (725.71±108.82) dyns/cm 5 , (1 125.27±152.23) dyns/cm 5 , which were
significantly lower than that of the control group. Conclusion: Adding alprostadil based on
conventional frequent ventilation thraphy can effectively improve blood pressure and oxygen
saturation, and improve hemodynamics of newborns with persistent pulmonary hypertension,
which has important clinical value.
| Reference Key |
zhang2017journaleffects
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|---|---|
| Authors | ;Lan Zhang;Yan Liu;Qiong Gao;Jing Zhang;Hui-Ping Wang |
| Journal | journal of communications |
| Year | 2017 |
| DOI |
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