cell and gene therapy approaches for cardiac vascularization

Clicks: 335
ID: 131661
2012
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Abstract
Despite encouraging preclinical results for therapeutic angiogenesis in ischemia, a suitable approach providing sustained, safe and efficacious vascular growth in the heart is still lacking. Vascular Endothelial Growth Factor (VEGF) is the master regulator of angiogenesis, but it also can easily induce aberrant and dysfunctional vascular growth if its expression is not tightly controlled. Control of the released level in the microenvironment around each cell in vivo and its distribution in tissue are critical to induce stable and functional vessels for therapeutic angiogenesis. The present review discusses the limitations and perspectives of VEGF gene therapy and of different cell-based approaches for the implementation of therapeutic angiogenesis in the treatment of cardiac ischemia.
Reference Key
banfi2012cellscell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Andrea Banfi;Anna Marsano;Friedrich Eckstein;Stefano Boccardo;Ludovic Melly
Journal Frontiers in psychology
Year 2012
DOI
10.3390/cells1040961
URL
http://www.mdpi.com/2073-4409/1/4/961
Keywords
cell therapy gene therapy angiogenesis cardiac tissue engineering

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