cord blood platelet rich plasma derivatives for clinical applications in non-transfusion medicine

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ID: 131440
2020
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Abstract
Cord blood platelet rich plasma (CB-PRP) derivatives have been investigated as potential therapeutic agents for the treatment of diverse conditions including ocular surface disease and skin ulcers. We have developed processes for the formulation of several CB-PRP preparations, which have different composition and attributes. Here we describe the molecular characteristics of these preparations and we make recommendations as to their most appropriate clinical application based on functional and immunomodulatory profiles. We show that incubation of adult peripheral blood mononuclear cells (PBMCs) with all three preparations dramatically reduced the production of INFγ and the expression of NKG2D and CD107a in NK, NKT, and T cells thus diminishing their activation, we propose that the likely mechanism is the high levels of soluble NKG2D ligands present in plasma. Of the three preparations we investigated, CB platelet lysate (PL) and platelet releaseate (PR) have higher concentrations of trophic and pro-angiogenic factors, CB platelet poor plasma (PPP) has the lowest concentration of all analytes measured. Based on these finding we propose that CB-PR is the most suitable raw material for skin wound patches, while CB-PL and PPP can be used to prepare eye drops for severe ocular surface pathologies and inflammatory conditions such as corneal ulcers or severe dry eye disease, respectively.
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samarkanova2020frontierscord Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Dinara Samarkanova;Dinara Samarkanova;Dinara Samarkanova;Steven Cox;Steven Cox;Diana Hernandez;Diana Hernandez;Luciano Rodriguez;Ricardo P. Casaroli-Marano;Ricardo P. Casaroli-Marano;Alejandro Madrigal;Alejandro Madrigal;Alejandro Madrigal;Sergio Querol;Sergio Querol
Journal sudebno-meditsinskaia ekspertiza
Year 2020
DOI
10.3389/fimmu.2020.00942
URL
https://www.frontiersin.org/article/10.3389/fimmu.2020.00942/full
Keywords
Plasma platelets cord blood allergy

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