markery zapalenia, aktywacja płytek krwi i zaburzenia krzepnięcia w chorobach zapalnych jelit

Clicks: 249
ID: 131398
2016
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Abstract
Inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn’s disease. It is a group of chronic disorders characterized by inflammation of the gastrointestinal track with unknown etiology. Currently applied biomarkers include CRP, ESR, pANCA, ASCA, and fecal calprotectin. The etiopathogenesis of IBD is multifactorial. In patients with IBD in inflamed alimentary tract mucosa the number of recruited monocytes and activated macrophages which are source of cytokines. In IBD, the exacerbation is accompanied by thrombocytosis. Platelets play a crucial role in the hemostasis and inflammatory response. Selectins, which regulates the hemostasis and inflammatory response, stimulates the secretion of many inflammatory mediators such as β-thromboglobuline, CD40L, fibrinogen, IL-1β, platelet factor-4. In the course of IBD the following changes are observed: an increase in the number of platelets (reactive thrombocytosis), PDW and PCT, reduction in MPV, increased production and excretion of granular content products (P-selectin, GP53, β-TG, PF-4, vWF, fibrinolytic inhibitors).
Reference Key
matowicka-karna2016postpymarkery Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Joanna Matowicka-Karna
Journal voprosy pitaniia
Year 2016
DOI
10.5604/01.3001.0009.6811
URL
http://phmd.pl/gicid/pdf/01.3001.0009.6811
Keywords
inflammatory bowel disease markers of inflammation ibd activationmedicine

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