engineering cytoplasmic signaling of cd28ζ cars for improved therapeutic functions

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ID: 130032
2020
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Abstract
Chimeric antigen receptor modified T cells (CAR-T) have yielded impressive clinical outcomes in treating hematopoietic malignancies. However, relapses have occurred in a substantial number of patients and limited the development of CAR-T therapy. Most underlying reasons for these relapses can be attributed to poor persistence and rapid exhaustion of CAR-T cells in vivo. Despite multiple strategies having been developed, how to improve CAR-T persistence or resist exhaustion while maintaining sufficient cytotoxic functions is still a great challenge. Here we discuss engineering cytoplasmic signaling as an important strategy for CAR optimization. This review summarizes recent advances showing that the anti-tumor function of CAR-T cells can be improved by optimizing the CD3ζ domain or downstream signaling of CD28ζ CAR.
Reference Key
meng2020frontiersengineering Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Xianhui Meng;Xianhui Meng;Xianhui Meng;Ruirui Jing;Ruirui Jing;Ruirui Jing;Liling Qian;Liling Qian;Liling Qian;Chun Zhou;Jie Sun;Jie Sun;Jie Sun
Journal sudebno-meditsinskaia ekspertiza
Year 2020
DOI
10.3389/fimmu.2020.01046
URL
https://www.frontiersin.org/article/10.3389/fimmu.2020.01046/full
Keywords
Cytotoxicity chimeric antigen receptor allergy

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