polymeric films as a promising carrier for bioadhesive drug delivery: development, characterization and optimization

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ID: 129613
2017
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Ranked #6 of 125 articles by views in International journal for quality in health care : journal of the International Society for Quality in Health Care

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Abstract
Bioadhesive films using tamarind seed polysaccharide were prepared for the treatment of candida vaginitis using nystatin as the model drug. Films were prepared by solvent casting method. A 32 factorial design was employed to study the effect of independent variables (polymer and plasticizer concentration) on a range of dependent variables namely mechanical, swelling, interfacial, and bioadhesive properties through response surface methodological approach, using Design Expert® software. Formulation composition that provided the most desired and optimized results was selected using desirability approach. Nystatin was solubilized using Tween 60 and was incorporated into the selected film. Drug solubilization and dispersion were confirmed by scanning electron microscopy and differential scanning calorimetry. The optimized film released 73.92 ± 2.54% of nystatin at the end of 8 h in simulated vaginal fluid and the release data showed best fit to Korsmeyer–Peppas model with R2 of 0.9990 and the release mechanism to be super case-II. The optimized film also showed appropriate anti candida activity through appearance of zone of inhibition during antifungal activity testing study.
Reference Key
bassi2017saudipolymeric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Pallavi Bassi;Gurpreet Kaur
Journal International journal for quality in health care : journal of the International Society for Quality in Health Care
Year 2017
DOI
10.1016/j.jsps.2015.06.003
URL
http://www.sciencedirect.com/science/article/pii/S1319016415001140
Keywords
response surface methodology polymeric films candidiasis pharmacology

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