new insights into vaca intoxication mediated through its cell surface receptors

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ID: 129255
2016
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Abstract
Helicobacter pylori (H. pylori), a major cause of gastroduodenal diseases, produces VacA, a vacuolating cytotoxin associated with gastric inflammation and ulceration. The C-terminal domain of VacA plays a crucial role in receptor recognition on target cells. We have previously identified three proteins (i.e., RPTPα, RPTPβ, and LRP1) that serve as VacA receptors. These receptors contribute to the internalization of VacA into epithelial cells, activate signal transduction pathways, and contribute to cell death and gastric ulceration. In addition, other factors (e.g., CD18, sphingomyelin) have also been identified as cell-surface, VacA-binding proteins. Since we believe that, following interactions with its host cell receptors, VacA participates in events leading to disease, a better understanding of the cellular function of VacA receptors may provide valuable information regarding the mechanisms underlying the pleiotropic actions of VacA and the pathogenesis of H. pylori-mediated disease. In this review, we focus on VacA receptors and their role in events leading to cell damage.
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yahiro2016toxinsnew Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Kinnosuke Yahiro;Toshiya Hirayama;Joel Moss;Masatoshi Noda
Journal matec web of conferences
Year 2016
DOI
10.3390/toxins8050152
URL
http://www.mdpi.com/2072-6651/8/5/152
Keywords
receptors low-density lipoprotein receptor-related protein-1 (lrp1)medicine

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