colonic microbiota encroachment correlates with dysglycemia in humanssummary

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ID: 128566
2017
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Abstract
Background and Aims: Mucoid structures that coat the epithelium play an essential role in keeping the intestinal microbiota at a safe distance from host cells. Encroachment of bacteria into the normally almost-sterile inner mucus layer has been observed in inflammatory bowel disease and in mouse models of colitis. Moreover, such microbiota encroachment has also been observed in mouse models of metabolic syndrome, which are associated low-grade intestinal inflammation. Hence, we investigated if microbiota encroachment might correlate with indices of metabolic syndrome in humans. Methods: Confocal microscopy was used to measure bacterial-epithelial distance of the closest bacteria per high-powered field in colonic biopsies of all willing participants undergoing cancer screening colonoscopies. Results: We observed that, among all subjects, bacterial-epithelial distance was inversely correlated with body mass index, fasting glucose levels, and hemoglobin A1C. However, this correlation was driven by dysglycemic subjects, irrespective of body mass index, whereas the difference in bacterial-epithelial distance between obese and nonobese subjects was eliminated by removal of dysglycemic subjects. Conclusions: We conclude that microbiota encroachment is a feature of insulin resistance–associated dysglycemia in humans. Keywords: Metabolic Syndrome, Mucus Layer, Microbiota
Reference Key
chassaing2017cellularcolonic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Benoit Chassaing;Shreya M. Raja;James D. Lewis;Shanthi Srinivasan;Andrew T. Gewirtz
Journal pamukkale university journal of engineering sciences
Year 2017
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2352345X17300759
Keywords
Gastroenterology

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