Abscisic Acid Standardized Fig () Extracts Ameliorate Postprandial Glycemic and Insulinemic Responses in Healthy Adults.

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ID: 12417
2019
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Abstract
Abscisic acid (ABA) can improve glucose homeostasis and reduce inflammation in mammals by activating lanthionine synthetase C-like 2 (LANCL2). This study examined the effects of two fig fruit extracts (FFEs), each administered at two different ABA doses, on glycemic index (GI) and insulinemic index (II) to a standard glucose drink. In a randomized, double-blind crossover study, 10 healthy adults consumed 4 test beverages containing FFE with postprandial glucose and insulin assessed at regular intervals over 2 h to determine GI and II responses. Test beverages containing 200 mg FFE-50× and 1200 mg FFE-10× significantly reduced GI values by -25% ( = 0.001) and -24% ( = 0.002), respectively. Two lower doses of FFE also reduced GI values compared with the reference drink (by approximately -14%), but the differences did not reach statistical significance. Addition of FFE to the glucose solution significantly reduced II values at all dosages and displayed a clear dose-response reduction: FFE-50× at 100 mg and 200 mg (-14% ( < 0.05) and -24% ( = 0.01), respectively) and FFE-10× at 600 mg and 1200 mg (-16% ( < 0.05) and -24% ( = 0.01), respectively). FFE supplementation is a promising nutritional intervention for the management of acute postprandial glucose and insulin homeostasis, and it is a possible adjunctive treatment for glycemic management of chronic metabolic disorders such as prediabetes and type 2 diabetes mellitus.
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atkinson2019abscisicnutrients Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Atkinson, Fiona S;Villar, Agusti;Mulà, Anna;Zangara, Andrea;Risco, Ester;Smidt, Carsten R;Hontecillas, Raquel;Leber, Andrew;Bassaganya-Riera, Josep;
Journal Nutrients
Year 2019
DOI
E1757
URL
Keywords Keywords not found

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