Generation of four induced pluripotent stem cell lines (FHUi003-A, FHUi003-B, FHUi004-A and FHUi004-B) from two affected individuals of a familial neurohypophyseal diabetes insipidus family.

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ID: 121928
2020
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Abstract
Four disease-specific induced pluripotent stem cell (iPSC) lines were respectively derived from peripheral blood mononuclear cells of two affected individuals in a family affected by familial neurohypophyseal diabetes insipidus carrying the c.314G>C mutation. The expression of pluripotency markers (NANOG, OCT4, and SOX2), maintenance of a normal karyotype, absence of episomal vectors used for iPSC generation, and presence of the original pathogenic mutation were confirmed for each iPSC line. The ability to differentiate into three germ layers was confirmed by a teratoma formation assay. These iPSC lines can help in disease recapitulation in vitro using organoids and elucidation of disease mechanisms.
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yoshida2020generationstem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yoshida, Satoru;Okura, Hanayuki;Suga, Hidetaka;Soen, Mika;Kawaguchi, Yohei;Kurimoto, Junki;Miyata, Takashi;Takagi, Hiroshi;Arima, Hiroshi;Fujikawa, Tatsuya;Otsuka, Fumio;Matsuyama, Akifumi;
Journal Stem cell research
Year 2020
DOI
S1873-5061(20)30261-0
URL
Keywords
multi-views learning spectral clustering weighted tensor nuclear norm

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