Effect of dexamethasone on serum protein extravasation in experimental brain infarcts of monkey: An immunohistochemical study

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ID: 121402
1970
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Abstract
Experimental brain infarcts were produced in 12 adult baboons (Papio cynocephalus) by transorbital permanent clipping of the left middle cerebral artery. One group (seven monkeys) received daily injections of 1 mg/kg dexamethasone, starting 1 h after vascular occlusion and continuing till the end of the experiment. Another group (five monkeys) was not treated. One week after vascular occlusion the volume of infarcts and peri-infarct edema was estimated morphometrically on histological sections, using Masson's trichrome stain and the peroxidase-anti-peroxidase (PAP) technique for visualization of serum protein extravasation. In the untreated animals the average volume of infarct was 6.57±4.23% (mean±SD) and the volume of edema 7.83±2.93% of ipsilateral hemisphere. In the treated animals the infarct volume was not different (7.95±3.00%), but the volume of peri-infarct edema was significantly lower (2.82±3.06%,p<0.05). The results obtained indicate that dexamethasone treatment reduces the development of peri-infarct edema but does not influence the size of infarcts.
Reference Key
barbosa-coutinho1970actaeffect Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors L. M. Barbosa-Coutinho;A. Hartmann;K. -A. Hossmann;T. Rommel;L. M. Barbosa-Coutinho;A. Hartmann;K. -A. Hossmann;T. Rommel;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00687005
URL
https://link.springer.com/article/10.1007/BF00687005
Keywords
pathology neurosciences

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