Pharmacodynamics of levofloxacin and ciprofloxacin in a murine pneumonia model: peak concentration/MIC versus area under the curve/MIC ratios

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ID: 120431
2003
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Resumo
During the last decade some studies have shown that the area under the curve (AUC)/MIC ratio is the pharmacodynamic index that best predicts the efficacies of quinolones, while other studies suggest that the predictive value of the peak concentration/MIC (peak/MIC) ratio is superior to the AUC/MIC r …
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Autores Scaglione F;Mouton JW;Mattina R;Fraschini F;;
Periodico Antimicrobial agents and chemotherapy
Ano 2003
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http://www.ncbi.nlm.nih.gov/pubmed/12936969
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National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Survival Analysis pneumonia pneumococcal / microbiology microbial sensitivity tests anti-infective agents / therapeutic use ciprofloxacin / therapeutic use microbial dose-response relationship drug levofloxacin* area under curve ofloxacin / therapeutic use protein binding colony count anti-infective agents / pharmacokinetics* streptococcus pneumoniae / drug effects pneumococcal / drug therapy pmid:12936969 pmc182632 doi:10.1128/aac.47.9.2749-2755.2003 f scaglione j w mouton f fraschini ciprofloxacin / pharmacokinetics* ofloxacin / pharmacokinetics* pneumococcal / metabolism*

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