Neuroendocrine androgen action is a key extraovarian mediator in the development of polycystic ovary syndrome

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ID: 119028
2017
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Ranked #16 of 292 articles by views in Proceedings of the National Academy of Sciences of the United States of America

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Abstract
Polycystic ovary syndrome (PCOS) is a complex hormonal disorder characterized by reproductive, endocrine, and metabolic abnormalities. As the origins of PCOS remain unknown, mechanism-based treatments are not feasible and current management relies on treatment of symptoms. Hyperandrogenism is the mo …
Reference Key
asl2017proceedingsneuroendocrine Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Caldwell Asl, Edwards MC, Desai R, Jimenez M, Gilchrist RB, Handelsman DJ, Walters KA
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Journal Proceedings of the National Academy of Sciences of the United States of America
Year 2017
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/28320971
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female Disease Models animal* Cells Cultured Receptors Knockout polycystic ovary syndrome / metabolism polycystic ovary syndrome / pathology* neurons / drug effects neurons / metabolism androgens / pharmacology* melissa c edwards kirsty a walters pmid:28320971 pmc5402450 doi:10.1073/pnas.1616467114 aimee s l caldwell estrous cycle / drug effects granulosa cells / drug effects granulosa cells / metabolism granulosa cells / pathology* neurons / pathology* neurosecretory systems / drug effects* polycystic ovary syndrome / drug therapy androgen / physiology*

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