The effect of amyloidosis-β and ageing on proliferation of neuronal progenitor cells in APP-transgenic mouse hippocampus and in culture
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ID: 118628
2008
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Abstract
Stimulation of endogenous neurogenesis and transplantation of neuronal progenitors (NPs) are considered in therapy of neuronal loss associated with ageing and in neurodegenerative diseases with amyloidosis-β, for example, Alzheimer’s disease and Down syndrome. However, the influence of brain environment altered by ageing and deposits of amyloid-β on proliferation of endogenous and transplanted NPs and their maturation into neurons is not understood. We studied the effect of ageing and development of amyloidosis-β on proliferation of NPs (1) in the granular layer of dentate gyrus in the hippocampi of APP-transgenic mice (Tg9291) before and after development of amyloidosis-β, that is, in mice aged 2–4 months and 9–12 months, respectively, and in age-matched controls; and (2) in culture of NPs isolated from brains of control and Tg9291 mice, aged 3 and 9 months. We found that the number of proliferating NPs was reduced in 9–12-months-old mice, in both control and Tg9291, as compared to 2–4-months-old mice. However, the 9–12-months-old Tg9291 mice with amyloid-β deposits had significantly more proliferating NPs than the age-matched controls. NPs proliferation in culture did not depend on the age, presence of APP-transgene, and amyloidosis-β in donors. The results indicate that the local brain environment influences proliferation of NPs, and development of amyloidosis-β in the neurogenic regions attenuates the age-associated reduction of proliferation of NPs. Identification of the responsible mechanisms may be important for development of a successful therapy of neurodegeneration caused by amyloidosis-β.
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| Authors | Radek Kolecki;Giuseppe LaFauci;Richard Rubenstein;Bozena Mazur-Kolecka;Wojciech Kaczmarski;Janusz Frackowiak;Radek Kolecki;Giuseppe LaFauci;Richard Rubenstein;Bozena Mazur-Kolecka;Wojciech Kaczmarski;Janusz Frackowiak; |
| Journal | acta neuropathologica |
| Year | 2008 |
| DOI |
doi:10.1007/s00401-008-0380-4
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