Progression of myopathology in Kearns-Sayre syndrome: a morphological follow-up study
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ID: 118369
1970
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Abstract
We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy.
| Reference Key |
reichmann1970actaprogression
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| Authors | Heinz Reichmann;R. Gold;B. Meurers;M. Naumann;P. Seibel;U. Walter;T. Klopstock;Heinz Reichmann;R. Gold;B. Meurers;M. Naumann;P. Seibel;U. Walter;T. Klopstock; |
| Journal | acta neuropathologica |
| Year | 1970 |
| DOI |
doi:10.1007/BF00334681
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