Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity

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ID: 118268
1999
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Abstract
Mice deficient in C/EBP alpha have defective development of adipose tissue, but the precise role of C/EBP alpha has not been defined. Fibroblasts from C/EBP alpha(-/-) mice undergo adipose differentiation through expression and activation of PPAR gamma, though several clear defects are apparent. C/E …
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Authors Wu Z;Rosen ED;Brun R;Hauser S;Adelmant G;Troy AE;McKeon C;Darlington GJ;Spiegelman BM;;
Journal molecular cell
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10078198
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Post-Translational animals pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't P.H.S. enhancer elements Adipose Tissue / metabolism* Lipid Metabolism Knockout Promoter Regions e d rosen glucose / metabolism cell differentiation insulin resistance / physiology* b m spiegelman phosphoproteins / biosynthesis phosphorylation fibroblasts / cytology protein processing adipose tissue / cytology phosphoproteins / genetics insulin / physiology* pmid:10078198 doi:10.1016/s1097-2765(00)80306-8 z wu adipose tissue / drug effects fibroblasts / drug effects fibroblasts / pathology* insulin / pharmacology insulin receptor substrate proteins receptor insulin / biosynthesis insulin / genetics

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