Glial changes in vitro induced by the inhibitor of succinic dehydrogenase

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ID: 118257
1970
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Abstract
The object of the experiment was to obtainin vitro the glial changes typical of hepatogenic encephalopathy, after inhibition of one of the stages of the Krebs cycle. A chemical inhibitor of succinic dehydrogenase, sodium malonate, was added to the culture medium in various concentrations. The experiment was carried out in four groups. The damage to the metabolism of the Krebs cycle resulted in the appearance of typical Opalski cells and intermediate cell forms. These pathological cells exhibited the same morphological and histochemical properties as those observed in experimental hepatogenic encephalopathy in vivo and in vitro. The striking feature of the Opalski cells was a significant decrease of SDH and GDH activity. The authors discuss the possible pathogenesis of the glial changes which are probably due to the disturbance of ammonia detoxication.
Reference Key
renkawek1970actaglial Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors K. Renkawek;Z. Kraśnicka;T. Majdecki;M. J. Mossakowski;K. Renkawek;Z. Kraśnicka;T. Majdecki;M. J. Mossakowski;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00697746
URL
https://link.springer.com/article/10.1007/BF00697746
Keywords
pathology neurosciences

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