Human immunodeficiency virus (HIV)-related chronic relapsing inflammatory demyelinating polyneuropathy with multifocal unusual onion bulbs in sural nerve biopsy

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ID: 118251
1970
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Abstract
This is obviously the first report on a case with a spontaneous sensu strictu relapsing variant of human immunodeficiency virus (HIV)-related polyneuropathy. Its manifestation preceded LAS. Intrathecal HIV-antibodies developed between the most severe third and fourth episode. Analysis of sural nerve biopsy was consistent with a multifocally accentuated chronic inflammatory demyelination, characterized by unusual onion bulb-like Schwann cell formations with irregular voluminous layers, electron density, aggregation of filaments, multiple indented nuclei, and numerous enclosed collagen pockets. A direct or immune-mediated indirect specific influence on Schwann cell morphology by HIV might be discussed. Virus-like particles and ultrastructural markers of HIV were not detectable.
Reference Key
gibbels1970actahuman Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors E. Gibbels;N. Diederich;E. Gibbels;N. Diederich;
Journal acta neuropathologica
Year 1970
DOI
doi:10.1007/BF00687143
URL
https://link.springer.com/article/10.1007/BF00687143
Keywords
pathology neurosciences

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