Boceprevir for untreated chronic HCV genotype 1 infection

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ID: 117918
2011
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Ranked #24 of 183 articles by views in The New England journal of medicine

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Abstract
The addition of boceprevir to standard therapy with peginterferon-ribavirin, as compared with standard therapy alone, significantly increased the rates of sustained virologic response in previously untreated adults with chronic HCV genotype 1 infection. The rates were similar with 24 weeks and 44 we …
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Authors Poordad F, McCone J, Bacon BR, Bruno S, Manns MP, Sulkowski MS, Jacobson IM, Reddy KR, Goodman ZD, Boparai N, DiNubile MJ, Sniukiene V, Brass CA, Albrecht JK, Bronowicki JP
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Journal The New England journal of medicine
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21449783
Keywords
hepatitis c National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't adult female male middle aged Comparative Study Clinical Trial Phase III Randomized Controlled Trial Double-Blind Method Multicenter Study Genotype viral / blood drug therapy combination antiviral agents / therapeutic use* recombinant proteins viral load ribavirin / therapeutic use hepacivirus / isolation & purification chronic / virology african continental ancestry group antiviral agents / adverse effects hepacivirus / genetics* chronic / drug therapy* interferon alpha-2 serine proteinase inhibitors / adverse effects serine proteinase inhibitors / therapeutic use* pmid:21449783 pmc3766849 doi:10.1056/nejmoa1010494 fred poordad jonathan mccone sprint-2 investigators anemia / chemically induced chronic / ethnology interferon-alpha / therapeutic use polyethylene glycols / therapeutic use proline / adverse effects proline / analogs & derivatives* proline / therapeutic use

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